In 2023, the U.S. reported over a million more sexually transmitted infections than in 2004, according to the CDC.Thousands of babies have syphilis.

Since 2013, gonorrhea rates have been consistently higher among men than women, largely due to cases among men who have sex with men (MSM). Data from the STI Surveillance Network (SSuN) suggests that MSM accounted for about half of gonorrhea cases in 2023, though this varied by jurisdiction.

Although sexually transmitted infections are still at an epidemic level in the US, scientists at the US Centers for Disease Control and Prevention are expressing cautious optimism about some decreases emerging in the newest data.